Projects, Resources & Funding
"Ask and it will be given to you; seek and you will find; knock and the door will be opened to you." - Matthew 7:7
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Research Focus
Research Focus
resource & Method development
resource & Method development
We build bioinformatics resources to bridge the gap across complex multi-omics data types (genomics, transcriptomics, proteomics, and structural biology) to help: (1) hypothesize variant effect on protein function, (2) analyze drug target ↔ disease pairs.
molecular effect of protein Mutations
molecular effect of protein Mutations
We use computational biology, biophysics, and statistics to develop methods to decipher the molecular effect of genetic/synthetic mutations on protein structure-function relationships.
Machine Learning for Drug Discovery
Machine Learning for Drug Discovery
Our lab develops AI/ML-driven innovative tools and technology for small-molecule hit identification using data from DNA-encoded library (DEL) screening, high-throughput screening (HTS), etc.
THE GENOMICS 2 PROTEINS / G2P PORTAL - A resource and discovery tool for linking genetic screening outputs to protein sequences and structures
THE GENOMICS 2 PROTEINS / G2P PORTAL - A resource and discovery tool for linking genetic screening outputs to protein sequences and structures
Learn more about The Project ↗️
For Code/APIs related to the portal, Click here ↗️
Read the G2P Portal Flagship Publication!
CHARACTERIZING AND MODELING MOLECULAR EFFECT OF GENETIC DISEASE MUTATIONS USING BIOLOGICALLY INTERPRETABLE PROTEIN FEATURES, BIOPHYSICS, AND STRUCTURAL BIOINFORMATICS
CHARACTERIZING AND MODELING MOLECULAR EFFECT OF GENETIC DISEASE MUTATIONS USING BIOLOGICALLY INTERPRETABLE PROTEIN FEATURES, BIOPHYSICS, AND STRUCTURAL BIOINFORMATICS
Project: Proteome-wide Mechanism-focused Characterization of Missense Mutations ↗️
Project: Modeling the Conformational Effect of UMOD mutations using Molecular Dynamics ↗️
Project: Clustering Loss and Gain-of-stability Sites in Proteins ↗️
DEL+ML Paradigm: DNA-Encoded Library & Machine Learning for Actionable Hit Discovery
DEL+ML Paradigm: DNA-Encoded Library & Machine Learning for Actionable Hit Discovery
Unraveling the conformational dynamics of UMOD protein variants in Autosomal Dominant Tubulointerstitial Kidney Disease
Unraveling the conformational dynamics of UMOD protein variants in Autosomal Dominant Tubulointerstitial Kidney Disease
Learn more about The Project ↗️
BUILDING METHODS FOR INTEGRATIVE PROTEIN STRUCTURE-FUNCTION ANALYSIS COMBINING FUNCTIONAL GENOMICS (Mutagenesis Readouts) AND STRUCTURAL BIOLOGY DATA and Identify 3D Clusters/Hotspots
BUILDING METHODS FOR INTEGRATIVE PROTEIN STRUCTURE-FUNCTION ANALYSIS COMBINING FUNCTIONAL GENOMICS (Mutagenesis Readouts) AND STRUCTURAL BIOLOGY DATA and Identify 3D Clusters/Hotspots
Learn more about The Project ↗️
Past and Current Funding
Past and Current Funding
Project: Expansion of the Genomics 2 Proteins (G2P) Portal as a Multi-omics Data and Technology Platform to Markedly Accelerate and Facilitate Scientific Discovery
Project: Predicting functional effects of genetic variants in ion channels
Project: Develop an in-silico druggability assessment pipeline for target-disease pairs using multiple lines of evidence (genetic, phenotypic, structural and functional).
Project: Development of A Discovery Portal to Interrogate Genetic Screening Outputs on Protein Structure
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